Concentration, distribution and expression of interleukin-5 in human nasal polyp tissues / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1386-1389, 2002.
Article
in En
| WPRIM
| ID: wpr-282178
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To study the concentration, distribution and expression of IL-5 in nasal polyp tissues and explore its significance in micro-environment differentiation of eosinophil accumulation.</p><p><b>METHODS</b>The concentration and expression of IL-5 in nasal polyp tissues of 40 patients were determined by ELISA and immunohistochemistry and inferior turbinate mucosa from patients with nasal polyps and healthy volunteers were used as control.</p><p><b>RESULTS</b>IL-5 concentration in polyp tissues was significantly higher than that in turbinate mucosa (P < 0.05). There was no significant difference in the turbinate mucosae between patients with nasal polyps and healthy volunteers (P > 0.05). IL-5 concentrations in polyp tissues were markedly higher in patients with allergic rhinitis compared with those without (P < 0.05). IL-5 concentrations had no correlation with age and sex (P > 0.05). 80.1% of the eosinophils were positive for IL-5 and 90.9% of IL-5 positive cells were eosinophils. Only 3.7% of lymphocytes and neutrophils were positive for IL-5; IL-5 was not detectable in epithelial cells. IL-5 expression in eosinophils of polyp tissues was remarkably stronger than that of the turbinate mucosa (P < 0.05); there was no significant difference in the the turbinate mucosae between patients with nasal polyps and healthy volunteers (P > 0.05). IL-5 expression of eosinophils in polyp tissue was significantly stronger in patients with allergic rhinitis compared with those without (P < 0.05). There was no significant difference in IL-5 expression in lymphocytes and neutrophils between polyp tissues and turbinate nasal mucosa (both P > 0.05).</p><p><b>CONCLUSION</b>IL-5 is the key cytokine in eosinophilic pathologic mechanisms in nasal polyp tissues.</p>
Full text:
1
Index:
WPRIM
Main subject:
Turbinates
/
Enzyme-Linked Immunosorbent Assay
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Lymphocytes
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Chemistry
/
Nasal Polyps
/
Interleukin-5
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Allergy and Immunology
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Eosinophils
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Nasal Mucosa
Limits:
Adult
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Female
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Humans
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Male
Language:
En
Journal:
Chinese Medical Journal
Year:
2002
Type:
Article