Effects of Valeriana officinalis var. latifolia on expression of transforming growth factor beta 1 in hypercholesterolemic rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 845-848, 2003.
Article
in Zh
| WPRIM
| ID: wpr-282229
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of Valeriana officinalis var latifolia(VOL) on expression of transforming growth factor beta 1 (TGF-beta 1) in hypercholesterolemic rats and study its possible mechanisms.</p><p><b>METHOD</b>Dietary-induced hypercholesterolemia was induced in male Wistar rats by given 4% cholesterol and 1% cholic acid diet for 16 weeks. Changes of serum lipid, urinary albumin, renal function and Mesangial matrix index were assessed. Moreover, immunohistochemical stain for TGF-beta 1 and type IV collagen were performed.</p><p><b>RESULT</b>VOL could reduce the serum levels of total cholesterol, low density lipoprotein, urinary albumin and serum creatinine. Light microscopy and immunohistochemical stain revealed that in the same time of lowing serum lipid, Mesangial matrix index was significantly reduced, accompanied by decreased expression of TGF-beta 1 and type IV collagen.</p><p><b>CONCLUSION</b>VOL has the protective effect on lipid-induced nephropathy, and the inhibition of TGF-beta 1 expression might be the mechanism of VOL on renal protection.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Pharmacology
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Plants, Medicinal
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Valerian
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Drugs, Chinese Herbal
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Chemistry
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Administration, Oral
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Transforming Growth Factor beta
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Rats, Wistar
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Plant Roots
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2003
Type:
Article