A comparison of the protective activity of liver injury induced by D-galact-osamine between huangqin-tang and their metabolites by human intestinal bacteria / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 842-844, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-282230
ABSTRACT
<p><b>OBJECTIVE</b>To compare the protective activity of liver injury induced by D-galactosamine (GalN) between Huangqin-Tang and their metabolites by human intestinal bacteria(HIB).</p><p><b>METHOD</b>The liver injuries in conventional and pseudo-germfree mice were induced by GalN. After oral administration of Huangqin-Tang and their metabolites mixtures by HIB, the serum transaminase (ALT and AST) activities were detected.</p><p><b>RESULT</b>In conventional mice, large and medium doses (20 and 10 g.kg-1) of Huangqin-Tang decoction significantly reduced the increase of serum ALT activity after 18 h GalN treatment. In pseudo-germfree mice, metabolites significantly reduced the ALT levels. However, Huangqing-Tang didn't affect the ALT levels in this kind of mice. To all of the animals, AST levels remained the same after oral Huangqin-tang or their metabolites.</p><p><b>CONCLUSION</b>The metabolism by intestinal bacteria plays a role in pharmacological effects of constituents of Chinese herbal medicine. The metabolites of the constituents by intestinal bacteria were the real active components in vivo.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Aspartate Aminotransferases
/
Bacteria
/
Blood
/
Drugs, Chinese Herbal
/
Chemistry
/
Administration, Oral
/
Protective Agents
/
Alanine Transaminase
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2003
Type:
Article
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