Protective effect of curcumin on experimental liver injury in mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 756-793, 2003.
Article
in Zh
| WPRIM
| ID: wpr-282247
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To Study the protective effect of curcumin on three models of experimental liver injury in mice.</p><p><b>METHOD</b>The experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal N), and Bacillus Calmette-Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice.</p><p><b>RESULT</b>Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.</p><p><b>CONCLUSION</b>Curcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Aspartate Aminotransferases
/
Blood
/
Carbon Tetrachloride Poisoning
/
Lipopolysaccharides
/
Protective Agents
/
Curcumin
/
Alanine Transaminase
/
Chemical and Drug Induced Liver Injury
/
Galactosamine
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2003
Type:
Article