Effects of yixintong on regulating cellular calcium channels

Si-cheng LI; Hua HUANG; Fei-ming ZHENG; De-liang WEN; Shang-wu MO

Effects of yixintong on regulating cellular calcium channels / 中国中药杂志

Si-cheng LI; Hua HUANG; Fei-ming ZHENG; De-liang WEN; Shang-wu MO.

China Journal of Chinese Materia Medica ; (24): 754-756, 2003.

Article in Zh | WPRIM | ID: wpr-282248

Responsible library: WPRO

ABSTRACT

ABSTRACT

OBJECTIVETo explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels.METHODThe effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique.RESULTYixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly.CONCLUSIONYixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.

Subject(s)

Animals; Female; Male; Rats; Aorta; Cell Biology; Calcium Channels; Crataegus; Chemistry; Drugs, Chinese Herbal; Pharmacology; Flavonoids; Pharmacology; Muscle, Smooth, Vascular; Cell Biology; Myocytes, Smooth Muscle; Plant Leaves; Chemistry; Plants, Medicinal; Chemistry; Rats, Wistar

Fulltext

Add to My VHL

XML

Search on Google

Full text: 1 Index: WPRIM Main subject: Aorta / Pharmacology / Plants, Medicinal / Flavonoids / Drugs, Chinese Herbal / Calcium Channels / Chemistry / Rats, Wistar / Plant Leaves / Crataegus Limits: Animals Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2003 Type: Article

Fulltext

Add to My VHL

XML

Search on Google