Possible association between polymorphisms of human leukocyte antigen-DQ genes and susceptibility to trichloroethylene-induced severe generalized dermatitis / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 173-176, 2006.
Article
in Zh
| WPRIM
| ID: wpr-282291
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between genetic polymorphisms of human leukocyte antigen-DQ (HLA-DQ) and susceptibility to trichloroethylene (TCE)-induced severe generalized dermatitis.</p><p><b>METHODS</b>A case-control study was conducted which included 112 patients with TCE-induced severe generalized dermatitis and 142 healthy controls exposed to TCE in the same workshop. The DNA sequences in exon2 of HLA-DQA1 and HLA-DQB1 were performed by direct sequencing of polymerase chain reaction (PCR) products. The frequencies distribution of allelic genotypes and codon polymorphisms were compared.</p><p><b>RESULTS</b>The frequencies of DQA1*0201 and 060101/0602 in cases [7.6% (17/224) and 16.1% (36/224)] were significantly higher than those of the exposed controls [3.5% (10/284) and 7.0% (20/284)], while frequencies of DQA1*0103 and 050101/0503/0505 in cases [5.8% (13/224) and 8.9% (20/224)] were significantly lower than those of exposed controls [10.9% (31/284) and 17.3% (49/284)]. In terms of codon polymorphisms, there were 5 codons of DQA1 (25, 41, 52, 54 and 69) showing significant differences between cases and controls. There were no significant differences in the frequencies of allelic genotypes of HLA-DQB1 between cases and exposed controls.</p><p><b>CONCLUSION</b>The genetic polymorphisms of HLA-DQA1 might be one of the factors influencing the individual susceptibility to TCE-induced severe generalized dermatitis.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Trichloroethylene
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HLA-DQ Antigens
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Occupational Exposure
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Drug Eruptions
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Genetic Predisposition to Disease
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Alleles
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Toxicity
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Gene Frequency
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Genetics
Type of study:
Observational_studies
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Preventive Medicine
Year:
2006
Type:
Article