Association between genetic variations in methylenetetrahydrofolate reductase and risk of colorectal cancer in a Chinese population / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 409-411, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-282320
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between genetic variations in methylenetetrahydrofolate reductase (MTHFR) and the risk of colorectal cancer in a Chinese population.</p><p><b>METHODS</b>One hundred and ninety-eight cases of colorectal cancer and 420 controls were genotyped for detecting MTHFR C677T and A1298C polymorphisms by PCR-RFLP methods. The adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated by using unconditional logistic regression model.</p><p><b>RESULTS</b>The frequency of the MTHFR C677T allele found among cases was significantly more frequent than that among controls (51.3% to 44.4%, P = 0.02). As compared with the 677CC genotype, the 677TT genotypes had a 67% (95% CI, 1.05 - 2.66) increased risk of colorectal cancers. However, there appeared no any correlations between the genetic variations of MTHFR and the cancer metastasis.</p><p><b>CONCLUSION</b>These findings demonstrated that the genetic variation of MTHFR C677T should be a genetic susceptibility factor for colorectal cancer in a Chinese population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Restriction Fragment Length
/
Colorectal Neoplasms
/
Logistic Models
/
Odds Ratio
/
China
/
Polymerase Chain Reaction
/
Risk Factors
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Methylenetetrahydrofolate Reductase (NADPH2)
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS