Meta-analysis of the effectiveness of plasma exchange in treatment of severe and acute organophosphate poisoning / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To discuss the effectiveness of severe and acute organophosphate poisoning (AOPP) treated with plasma exchange in China.</p><p><b>METHODS</b>Researches about effectiveness of severe AOPP treated with plasma exchange were analyzed by Review Manager 4.2 and fixed effect model of meta-analysis method were used.</p><p><b>RESULTS</b>Six trials including 433 patients were identified. Treatment group including 211 patients adopted traditional physician therapy plus plasma exchange, and control group including 222 patients received physician therapy only. The case-fatality rate of the treatment group was lower than the control one [RR=0.30, 95%CI (0.19-0.49), P<0.01].</p><p><b>CONCLUSION</b>Plasma exchange can improve the cure rate of severe AOPP.</p>