Your browser doesn't support javascript.
loading
Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 816-819, 2011.
Article in Chinese | WPRIM | ID: wpr-282502
ABSTRACT
<p><b>OBJECTIVE</b>To study mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4 and T-bet) in peripheral blood of the patients with allergic dermatitis induced by trichloroethylene (TCE).</p><p><b>METHODS</b>The peripheral blood samples were collected from 8 healthy workers (control group) and 8 patients with allergic dermatitis induced by TCE (case group). Real-time quantitative PCR was applied to detect mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4, T-bet).</p><p><b>RESULTS</b>The mRNA expression levels of Foxp3, GATA3 and CTLA4 genes increased by 115%, 97% and 241% in case group, as compared with control group (P < 0.01). The mRNA expression level of T-bet gene decreased by 47% in case group, as compared with control group (P < 0.01).</p><p><b>CONCLUSION</b>The mRNA expression levels of some immune-related genes changed in patients with allergic dermatitis induced by TCE, those genes may play an important role in TCE-induced allergy.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Trichloroethylene / RNA, Messenger / Case-Control Studies / Gene Expression / Dermatitis, Occupational / T-Box Domain Proteins / Allergy and Immunology / GATA3 Transcription Factor / Forkhead Transcription Factors / CTLA-4 Antigen Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2011 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Trichloroethylene / RNA, Messenger / Case-Control Studies / Gene Expression / Dermatitis, Occupational / T-Box Domain Proteins / Allergy and Immunology / GATA3 Transcription Factor / Forkhead Transcription Factors / CTLA-4 Antigen Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2011 Type: Article