Antibiotic Susceptibilities of Ocular Isolates from Patients with Bacterial Ke ratitis: A Multi-center Study

ABSTRACT

This multi-center study was performed prospectively to evaluate the causative organisms and antibiotic sensitivity of isolates in bacterial keratitis from April 1995 to December 1998. Total number of infectious keratitis was 1002 cases. Among them,279 cases were confirmed with bacterial keratitis and 314 strains were identified. Major causative organisms of bacterial keratitis were Pseudomonas aeruginosa 121 strains (38.54%), coagulase negative staphylococcus (CNS) 34 strains (10.83%), Streptococcus pneumoniae 19 strains (6.81%), Staphylococcus aureus 18 strains (5.73%), and Serratia marscence 16 strains (5.10%). P.aeruginosa was highly sensitive to ciprofloxacin, ceftazidime, piperacillin, cefoperazone, imipenem,tobramicin,and gentamycin. Coagulase negative streptococcus showed high sensitivity to vancomycin, teicoplanin, clindamycin, and ciplofloxacin, but low sensitivity to penicillin and gentamycin. In conclusion, the choice of the effective antibiotics in the treatment of bacterial keratitis were essential to decrease resistant bacterial strains.