Characterization of the changes in comparative genomic hybridization in esophageal cancer patients with family history / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1166-1169, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-282592
ABSTRACT
<p><b>OBJECTIVE</b>To characterize the profile of chromosomal imbalances in esophageal cancer (EC) with or without family history in Linzhou, Henan Province of China.</p><p><b>METHODS</b>Comparative genomic hybridization (CGH) was used to examine 13 cases with positive family history of EC and 32 cases with negative family history of EC. RESULTS DNA copy number gains on chromosome 10q was observed only in the cases with postivie family history of EC (30%), and none in cases with a negative family history (P<0.05). DNA copy number losses on chromosome 15q were significantly higher in cases with postivie family history (38% vs 6%, P<0.05). The frequency of DNA copy number gains in 3q, 5p, 7p, 8q and DNA copy number losses in 3p, 19q, 9q were similar in the two groups (both beyond 20%) (P>0.05).</p><p><b>CONCLUSIONS</b>Frequent DNA copy number gains on chromosome 10q and losses on chromosome 15q in EC casers with postivie family history indicate that these chromosome sites may harbor the genes related to high susceptibility to EC. Such chromosomal sites as 3q, 5p, 7p, 8q, 3p, 19q, and 9q may contain important genes related with the environmental risk factors of esophageal carcinogenesis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chromosomes, Human, Pair 10
/
Chromosomes, Human, Pair 15
/
Esophageal Neoplasms
/
China
/
Family Health
/
Gene Deletion
/
Genetic Predisposition to Disease
/
Chromosome Disorders
/
Comparative Genomic Hybridization
/
Genetics
Type of study:
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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