Changes of endothelial cell function and platelet activation in rabbit spinal cord with ischemia-reperfusion injury / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1638-1640, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-282627
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes of vascular endothelial cell function and platelet activation in rabbit spinal cord following ischemia-reperfusion (I/R) injury and their roles in the spinal cord injury.</p><p><b>METHODS</b>Rabbit spinal cord I/R injury models were established using Zivin method, and the changes in plasma NO and GMP140 levels were dynamically monitored after the injury.</p><p><b>RESULTS</b>Plasma NO level increased significantly in the I/R group at the end of the ischemia, and reached the peak level at 2 h of reperfusion as compared to that in sham-operated group (P<0.01). Plasma NO level decreased at 6 h of reperfusion, but still significantly higher than the level in the sham-operated group (P<0.05). Plasma GMP140 underwent no significant changes in the sham-operated group, but significantly increased in the I/R group at the end of the ischemia, followed by gradual declination to the normal level at 2 h of reperfusion.</p><p><b>CONCLUSION</b>Spinal cord I/R injury causes overexpressions of NO and GMP140, suggesting the involvement of endothelial cell injury and platelet overactivation in the pathological process and repair of spinal cord I/R injury.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Spinal Cord
/
Blood
/
Reperfusion Injury
/
Platelet Activation
/
P-Selectin
/
Endothelial Cells
/
Metabolism
/
Nitric Oxide
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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