Expression of pituitary tumor-transforming gene in patients with multiple myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1143-1145, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-282713
ABSTRACT
To explore the expression of pituitary tumor-transforming gene (PTTG) in elderly patients with multiple myeloma (MM) and its relationship with MM, the expressions of PTTG mRNA were detected in bone marrow mononuclear cells (BMMNC) from 33 patients with MM and 10 normal controls by using reverse transcriptase-polymerase chain reaction (RT-PCR). The results showed that the expression of PTTG mRNA in MM patients (0.3415 +/- 0.2172) was significantly higher than that in normal controls (0.0590 +/- 0.0233) (P < 0.05). It is concluded that the overexpression of oncogene PTTG may be related to genesis and progression of MM. It provided a new ideas to study the pathogenesis and gene therapy for MM patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Bone Marrow Cells
/
Gene Expression Regulation, Neoplastic
/
Reverse Transcriptase Polymerase Chain Reaction
/
Securin
/
Genetics
/
Metabolism
/
Multiple Myeloma
/
Neoplasm Proteins
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2006
Type:
Article
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