Expression of Ki-67 and Bcl-2 in adults and children with acute lymphoblastic leukemia and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 887-890, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-282769
ABSTRACT
To evaluate the expressions of proliferative antigen Ki-67 and apoptosis-antagonizing protein Bcl-2 as well as their clinical significance, immunohistochemistry staining with SAP was used to detect Ki-67 antigen and Bcl-2 protein in 18 cases of children with acute lymphoblastic leukemia (ALL) and 43 cases of adults with ALL. The results showed that the levels of Ki-67 and Bcl-2 expression in children with ALL were lower than that in adults, but only Bcl-2 expression had significant difference. Both in children and in adults, the levels of Ki-67 expression in T-ALL and My(+) ALL were higher than that in B-ALL and null-ALL. The highest complete remission rate (CR) was seen in the group with lower expression of both indexes (Ki-67 and Bcl-2). The lowest CR rate was seen in the group with higher expression of both indexes. It is concluded that the levels of Ki-67 and Bcl-2 expression in children and adults with ALL were closely related with the subtype of ALL and chemotherapeutic effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Antineoplastic Combined Chemotherapy Protocols
/
Apoptosis
/
Ki-67 Antigen
/
Proto-Oncogene Proteins c-bcl-2
/
Therapeutic Uses
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Metabolism
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2006
Type:
Article
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