Role of the cut-off value of serum neuron-specific enolase in differentiating small cell lung cancer from non-small cell lung cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 858-859, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-282896
ABSTRACT
<p><b>OBJECTIVE</b>To determine the cut-off value of serum neuron-specific enolase (NSE) level for distinguishing small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>Serum NSE levels were measured by enzyme-linked immunosorbent assay in 137 patients with NSCLC or SCLC, and the best cut-off value was analyzed using ROC curve.</p><p><b>RESULTS</b>The positivity rate of serum NSE was significantly higher in patients with SCLC than in those with NSCLC (P<0.01). The best cut-off value was 15.45 microg/L using ROC curve, which gave a sensitivity of 66.7% and specificity of 65.7%.</p><p><b>CONCLUSION</b>Serum NSE level may allow simple and cost-effective differentiation of SCLC and NSCLC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Phosphopyruvate Hydratase
/
Blood
/
Biomarkers, Tumor
/
Carcinoma, Small Cell
/
Carcinoma, Non-Small-Cell Lung
/
Diagnosis, Differential
/
Lung Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS