Clinical significance of antineutrophil cytoplasmic antibodies in patients with lupus nephritis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 833-836, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-282903
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical features of patients with lupus nephritis positive for antineutrophil cytoplasmic antibodies (ANCA) and explore the clinical implications of ANCA detection.</p><p><b>METHODS</b>Totally 261 patients with lupus nephritis were enrolled in this study, including 53 ANCA-positive and 208 ANCA-negative ones. The clinical data of the patients pertaining to the disease history, physical examination, laboratory examinations and pathological inspection were retrospectively analyzed.</p><p><b>RESULTS</b>Compared with patients negative for ANCA, the ANCA-positive patients had significantly higher incidence of serositis (75.5%), acute renal failure (64.2%), myocarditis (30.2%), neuropsychiatric involvement (26.4%) and lung hemorrhage (7.5%)(P<0.05). Significant differences were also found between the two groups in SLE disease active index (SLE-DAI), number of the diagnostic criteria, erythrocyte sedimentation rate (ESR), anemia, anti-Sm antibodies, and serum complement C(3). Most patients positive for ANCA (67.9%) had type IV lupus nephritis with more crescent formation, renal tubular atrophy, hyaline thrombi, and higher mortality rate as well than the negative patients.</p><p><b>CONCLUSION</b>ANCA detection may benefit the estimation of the disease severity and prognostic evaluation of lupus nephritis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Blood
/
Lupus Nephritis
/
Enzyme-Linked Immunosorbent Assay
/
Retrospective Studies
/
Antibodies, Antineutrophil Cytoplasmic
/
Allergy and Immunology
/
Immunologic Factors
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article
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