Establishment of hepatic metastatic subline of nasopharyngeal carcinoma cell line / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To establish a hepatic metastatic subline of nasopharyngeal carcinoma (NPC) cell line.</p><p><b>METHODS</b>NPC cells metastatic to the liver were isolated from nude mice and the invasion and metastatic ability of the cells was observed in vivo and in vitro.</p><p><b>RESULTS AND CONCLUSION</b>The invasion and metastasis activity of 5-8F-H3B-EGFP (an in vivo isolate with enhanced liver metastatic behaviors) were enhanced obviously in comparison with the parent cell line 5-8F-EGFP. This subline may be useful for cloning genes related to liver metastasis of NPC.</p>