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Total Lesion Glycolysis Using 18F-FDG PET/CT as a Prognostic Factor for Locally Advanced Esophageal Cancer
Journal of Korean Medical Science ; : 39-46, 2016.
Article in English | WPRIM | ID: wpr-28306
ABSTRACT
Standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) have been considered prognostic factors for survival in many cancers. However, their prognostic value for radiotherapy-treated squamous esophageal cancer has not been evaluated. In this study, SUV, MTV, and TLG were measured to predict their prognostic role in overall survival (OS) in 38 esophageal cancer patients who had undergone 18F-FDG PET/CT before radiotherapy. TLG demonstrated higher sensitivity and specificity for predicting OS than MTV and SUV; and a better OS was observed in patients with low TLG compared to those with high TLG in locally advanced disease (OS, 46.9 months; 95% confidence interval [CI], 33.50-60.26 vs. 25.3 months; 95% CI, 8.37-42.28; P=0.003). Multivariate analyses in these patients determined that TLG and the use of combination chemotherapy were the independent prognostic factors for OS (hazard ratio [HR], 7.12; 95% CI, 2.038-24.857; P=0.002 and HR, 6.76; 95% CI, 2.149-21.248; P=0.001, respectively). These results suggest that TLG is an independent prognostic factor for OS and a better predictor of survival than MTV and SUV in patients with locally advanced esophageal cancer treated with radiotherapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Esophageal Neoplasms / Tomography, X-Ray Computed / Proportional Hazards Models / Survival Rate / Retrospective Studies / ROC Curve / Radiopharmaceuticals / Area Under Curve / Fluorodeoxyglucose F18 Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Esophageal Neoplasms / Tomography, X-Ray Computed / Proportional Hazards Models / Survival Rate / Retrospective Studies / ROC Curve / Radiopharmaceuticals / Area Under Curve / Fluorodeoxyglucose F18 Type of study: Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2016 Type: Article