Expression of B7-H1 on peripheral blood mononuclear cells from chronic hepatitis B patients / 南方医科大学学报
Journal of Southern Medical University
; (12): 1635-1637, 2007.
Article
in Zh
| WPRIM
| ID: wpr-283069
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of B7-H1 on peripheral blood mononuclear cells from patients with chronic HBV infection.</p><p><b>METHODS</b>Immunofluorescent staining and flow cytometry assay were used to measure the expression of B7-H1 on peripheral blood CD3high T cells, CD19high B cells and CD14high monocytes from chronic HBV infected patients.</p><p><b>RESULTS</b>No significant difference was observed in B7-H1 expression on T cells and B cells between chronic HBV infected patients (CHB) and health controls (HC). B7-H1-expressing CD14high cells were significantly increased in chronic HBV-infected patients (19.17-/+11.64)% as compared with healthy controls [(7.30-/+5.49)%, P<0.01]. A significant positive correlation was found between B7-H1 expression on CD14high monocytes and serum ALT levels.</p><p><b>CONCLUSION</b>There is no significant difference in B7-H1 expression on T cells and B cells between CHB patients and healthy subjects. B7-H1, which is up-regulated on monocytes from chronic HBV-infected patients, in positively correlated to serum ALT levels, and may play a role in the persistence of HBV infection.</p>
Full text:
1
Index:
WPRIM
Main subject:
Leukocytes, Mononuclear
/
B-Lymphocytes
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Monocytes
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T-Lymphocytes
/
Antigens, CD
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Case-Control Studies
/
Hepatitis B, Chronic
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Allergy and Immunology
/
B7-H1 Antigen
/
Metabolism
Type of study:
Observational_studies
Limits:
Adult
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Aged
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Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article