Expression of C-erb B-2 and its relation to angiogenesis in nasopharyngeal carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1588-1589, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-283077
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of C-erb B-2 expression with angiogenesis in nasopharygeal carcinoma.</p><p><b>METHODS</b>Seventy-seven specimens of nasopharygeal carcinoma were examined immunohistochemically for protein expressions of C-erb B-2 and vascular endothelial growth factor (VEGF), and the microvessel density (MVD) was determined by immunostaining of the endothelial cells for factor VIII-related antigen (F8).</p><p><b>RESULTS</b>Positive C-erb B-2 immunostaining was observed in 36.36% (28/77) of the nasopharygeal carcinoma tissues, which had a VEGF positivity rate of 32.48% (25/77). High positivity rate of C-erg B-2 was associated with high positivity rate of VEGF and high MVD (P<0.05).</p><p><b>CONCLUSION</b>The expression of C-erb B-2 may contribute to angiogenesis in nasopharygeal carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Carcinoma
/
Gene Expression Regulation, Neoplastic
/
Nasopharyngeal Neoplasms
/
Receptor, ErbB-2
/
Vascular Endothelial Growth Factor A
/
Genetics
/
Metabolism
/
Neovascularization, Pathologic
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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