Chemical constituents from Bufonis periostracum and their antitumor activity in vitro / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2207-2210, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-283226
ABSTRACT
Eight compounds were isolated from Bufonis periostracum by repeated column chromatography on silica gel, ODS and Sephadex LH-20 and their structures were characterized as palmitatic acid cholesteryl ester (1), cholesterol (2), 5alpha, 8alpha-epidioxycholesta-6-en-3beta-ol (3), cholest-5-en-3beta, 7beta-diol (4), cholest-7-en-3beta, 5alpha, 6beta-triol (5), 3-octaddecyloxy-1, 2-propanediol (6), isisamide (7) and bufothionine (8) on the base of spectral analysis. Compounds 1-8 were isolated from Bufonis periostracum for the first time and compounds 3, 5, 6, 7 were obtained from Bufo bufo gargarizans and Bufo genus for the first time. The bioassays showed all tested samples displayed no antitumor activity against the cell lines such as A549, BeL 7402, HGC-27 and HL-60, except the control compound bufalin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Bufo bufo
/
Bufonidae
/
Metabolism
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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