A new water-soluble lubricant of tablets-L-leucine combined with PEG6000 / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2061-2065, 2011.
Article
in Zh
| WPRIM
| ID: wpr-283257
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare an effective and water-soluble lubricant.</p><p><b>METHOD</b>Co-sprayed lubricant (L-leucine and polyethylene glycol 6000 co-sprayed according to a certain proportion) and mixed lubricant (the physical mixture of spayed L-leucine and crushed polyethylene glycol 6000) were prepared and polyethylene glycol 6000, L-leucine, magnesium stearate, sodium stearyl fumarate and sodium chloride are crushed and sieved, respectively. Residual force, appearance of solution and disintegration time were considered as response variables of the lubrication effect to evaluate different lubricants. The changes of the co-sprayed lubricant were studied by differential scanning calorimetry, fourier infrared, electronic scanning microscope and X-ray diffraction.</p><p><b>RESULT</b>The efficacy of co-sprayed lubricant is better than other lubricants. Efficacy is improved by external form change without inner components and crystal changes.</p><p><b>CONCLUSION</b>Co-sprayed lubricant is a good water soluble tablet lubricant which has good efficacy.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polyethylene Glycols
/
Solubility
/
Tablets
/
X-Ray Diffraction
/
Water
/
Chemistry
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Chemistry, Pharmaceutical
/
Lubricants
/
Leucine
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article