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Effect of 5-fluorouracil in combination with Astragalus membranaceus on amino acid metabolism in mice model of gastric carcinoma / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 445-447, 2006.
Article in Chinese | WPRIM | ID: wpr-283299
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of 5-fluorouracil-FU in combination with astragalus membranaceus(AM) on amino acid metabolism in mice model of gastric carcinoma induced by 3-methylcholanthrene(MC).</p><p><b>METHODS</b>Mice gastric carcinoma models were established by 3-methylcholanthrene induction and randomly divided into different groups, and received 5-FU treatment (group A) 5-FU plus AM (group B), 5-FU plus a high dose of AM(group C), no treatment (group D). Normal mice were used as control (group N). Free amino acid in the tumor specimens were examined.</p><p><b>RESULTS</b>The levels of free Valine, Methionine, Leucine, Arginine and cystine in the tumor specimens in group D were significantly higher than that in group N(P< 0.05). The levels of free serine in group A, B, C, D were significantly higher than that in group N. The levels of free glutamic acid in group A, B were significantly higher than that in group N(P< 0.05). The levels of free proline in group C, D were significantly higher than that in group P, N(P< 0.05).</p><p><b>CONCLUSIONS</b>The increasing levels of free serine and proline in tumor specimens in gastric cancer mice model reveals metabolic disturbance of amino acid. 5-FU plus astragalus membranaceus can decrease the level of free glutamic acid in the mice models, and inhibit tumor growth.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Astragalus propinquus / Therapeutic Uses / Drug Therapy / Fluorouracil / Amino Acids / Phytotherapy / Metabolism / Mice, Inbred BALB C / Mice, Nude Limits: Animals Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stomach Neoplasms / Astragalus propinquus / Therapeutic Uses / Drug Therapy / Fluorouracil / Amino Acids / Phytotherapy / Metabolism / Mice, Inbred BALB C / Mice, Nude Limits: Animals Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2006 Type: Article