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Expressions and clinical implications of kruppel-like factor 6 and APC in human colorectal carcinoma / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 429-432, 2006.
Article in Chinese | WPRIM | ID: wpr-283303
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions and clinical implications of kruppel-like factor 6(KLF-6) and APC in human colorectal carcinoma.</p><p><b>METHODS</b>The expressions of KLF-6 and APC in tumor and normal tissues from 32 patients with colorectal carcinoma were investigated by RT-PCR and immunohistochemical technique.</p><p><b>RESULTS</b>The expression rates of KLF-6 and APC mRNA were 37.5% and 34.3% in tumor tissue, 96.9% and 93.8% respectively in normal tissues (both P< 0.05). The expression rates of KLF-6 and APC protein were 28.1% and 25.0% in colorectal carcinomas, 81.3% and 84.43% respectively in normal tissues (both P< 0.05). There was a significant correlation between the expressions of KLF-6 and APC in colorectal carcinomas (P < 0.05). The expressions of KLF-6 and APC were significantly correlated with tumor differentiation, depth of infiltration, lymph node metastasis and clinical stage (P< 0.05).</p><p><b>CONCLUSION</b>Down-regulations of KLF-6 and APC might play an important role in the carcinogenesis, development, metastasis of human colorectal carcinoma.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / RNA, Messenger / Colorectal Neoplasms / Gene Expression / Proto-Oncogene Proteins / Genes, APC / Adenomatous Polyposis Coli Protein / Kruppel-Like Transcription Factors / Kruppel-Like Factor 6 / Genetics Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / RNA, Messenger / Colorectal Neoplasms / Gene Expression / Proto-Oncogene Proteins / Genes, APC / Adenomatous Polyposis Coli Protein / Kruppel-Like Transcription Factors / Kruppel-Like Factor 6 / Genetics Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2006 Type: Article