Serotonin transporter gene polymorphism in slow transit constipation / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 328-330, 2006.
Article
in Zh
| WPRIM
| ID: wpr-283322
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the polymorphism of serotonin transporter gene-linked polymorphic region(5-HTTLPR) and slow transit constipation(STC).</p><p><b>METHODS</b>Polymerase chain reaction was used to assess 5-HTTLPR polymorphism of SERT gene in 54 patients with STC and 100 healthy controls.</p><p><b>RESULTS</b>The frequencies of serotonin transporter short/short(S/S) and allele S genotypes were significantly higher in STC patients than those in controls(72.2% vs 50.0%; 83.3% vs 72.5%; both P< 0.05). There were no significant differences in 5-HTTLPR polymorphism respectively between the two groups according to gender and age(less than 45 and more than 45 years old). The frequency of S/S genotype was higher in the patients with less than 40% of the ingested markers evacuated within 72 h than those with more than 40% evacuated(71.7% vs 42.6%, P< 0.05).</p><p><b>CONCLUSION</b>The presence of 5-HTTLPR allele S may contribute to the pathogenesis of STC.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Chronic Disease
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Constipation
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Alleles
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Serotonin Plasma Membrane Transport Proteins
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Gene Frequency
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Genetics
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Genotype
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2006
Type:
Article