The Prognostic Significance of Tumor Microvessel Density in Colorectal Carcinoma
Journal of the Korean Society of Coloproctology
;
: 719-724, 1998.
Article
in Korean
| WPRIM
| ID: wpr-28337
ABSTRACT
PURPOSE:
This study was carried out to evaluate the relationship with other clinicopath ologic factors and prognostic significance of tumor microvessel density in colorectal car cinoma. MATERIAL ANDMETHODS:
71cases of primary colorectal carcinoma (Modified Astler-Coller stage B and C) were analysed retrospectively who underwent curative resection at Wonkwang university hospital from September, 1991 to September, 1993. Male was 39cases. Age under 60 years was 31cases. 5 year survival rates were 80% (50 cases) in stage B and 52.4% (21 cases) in stage C. Tumor microvessels were stained by immuno histochemical method using anti-CD31 on paraffine embedded tissues, and were counted within 10x objective field (about 0.74 mm2) in the area of the most intense neovascu larization.RESULTS:
Mean microvessel Density (MVD) was 56.3+/-18.0 (range 19~128). MVD was 55.2 in 11 cases of nonrecurrent group and 73.5 in 10 cases of recurrent group in stage C (p=0.012). There was no significant association between MVD and other parameters such as age, sex, tumor location and size, CEA, lymph node metastasis, and survival. The 5 year survival rates of 33 cases of MVD56 were 84.9 and 60.5% respectively(p56 groups. 5 year survival rates of MVD 56 groups in stage C were 100% (5 cases) and 37.5% (16 cases) (p<0.05).CONCLUSION:
Tumor microvessl density may have somewhat prognostic significance in colorectal carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Recurrence
/
Colorectal Neoplasms
/
Survival Rate
/
Retrospective Studies
/
Microvessels
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Society of Coloproctology
Year:
1998
Type:
Article
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