Study on pharmacokinetics of crebanine injection in rabbits / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 630-632, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-283416
ABSTRACT
<p><b>OBJECTIVE</b>To develop an HPLC method for the determination of serum level of Crebanine (Cre) and study on the pharmacokinetics of Cre injection in rabbits.</p><p><b>METHOD</b>To sample blood serum from the rabbits' ears which were injected the Cre by 2.0 mg x kg(-1) at different time and use HPLC to determine the concentration of Cre in it, the pharmacokinetic parameters were accessed by the DAS software.</p><p><b>RESULT</b>Cre was fitted to a two compartment open pharmacokinetic model in rabbits. There was no signifiant difference between the male and female rabbits'pharmacokinetic by t-test. The mainly pharmacokinetic parameters were t1/2alpha = (3. 246 +/-0.222) min, t1/2beta = (36.67+/-5.52) min, Cmax = (1.401 +/- 0.062) mg x L(-1), Vd = (5.928 +/- 0.877) L x kg(-1), Cl = (0. 051 +/-0.003) L x min(-1) x kg(-1).</p><p><b>CONCLUSION</b>This experiment can objectively show the pharmacokinetics regularity of Crebanine injection in rabbits. Crebanine injection was a speeding disposition drug (t1/2 <1 h) and disposed extensively and rapidly in rabbits.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aporphines
/
Plants, Medicinal
/
Blood
/
Pharmacokinetics
/
Metabolic Clearance Rate
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Stephania
/
Injections
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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