Nephrotoxicity of Aristolochia manshriensis and Longdan Xiegan decoction / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 619-622, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-283419
ABSTRACT
<p><b>OBJECTIVE</b>To observe the renal function, histology and the levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) in rats administered with Aristolochi manshriensis (AM) and Longdan Xiegan decoction (LDXG) containing AM.</p><p><b>METHOD</b>Divided SD rats into control, AM and LDXG groups (n = 10 per group) at random and administrated orally for 8 weeks with distilled water, AM (6 g x kg(-1) x d(-1)) and LDXG (17. 5 g x kg(-1) x d(-1), containing AM 6 g x kg(-1) x d(-1)), respectively. Measured renal functional parameters in serum, urine and IL-1beta, IL-6 in renal homogenate, and observe renal histologic lesions at the end of 8 weeks.</p><p><b>RESULT</b>Two kinds of water abstract induced significantly renal injury in rats, IL-1beta, IL-6 levels in renal homogenate were significantly increased compared with controls, histological section showed inflammatory cell infiltration play important role in renal tubulointerstitium damage. LDXG caused less seriously damage than AM.</p><p><b>CONCLUSION</b>AM and LDXG in experimental dosage can induce renal injury, inflammatory cell infiltration in renal tubulointerstitium and high levels of IL-1beta, IL-6 presumpt that the nephrotoxicity of AM and LDXG refered to the immune mechanism. LDXG has light nephrotoxicity due to its restraining the inflammatory reaction caused by AM.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Plants, Medicinal
/
Proteinuria
/
Blood
/
Blood Urea Nitrogen
/
Drugs, Chinese Herbal
/
Random Allocation
/
Chemistry
/
Administration, Oral
/
Interleukin-6
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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