Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine the optimum technical parameters through controlling the different factors and the content of Dripping Pill.</p><p><b>METHOD</b>Time of dissolution, spherical degree and pill weight as parameters, the influential factors were investigated by orthogonal test and then to determine the content of liensinine, isoliensinine, neferine in plumula nelumbinis Alkaloid Dripping Pill.</p><p><b>RESULT</b>The optimum condition 75% PEG4000 as matrix, methyl-silicon oil as refrigerant, 4 cm dripping distance, 10 degrees C refrigerant, 30 drippings per minute.</p><p><b>CONCLUSION</b>The good quality pills can be produced through this process and the HPLC determination method is simple, reliable and can be used in the quality control of plumula nelumbinis Alkaloid Dripping Pill.</p>