Effects of Rhaponticum uniforum polysaccharide on immune response of mice after antigen stimulation and their possible mechanisms / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 433-435, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-283461
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Rhaponticum uniforum polysaccharide on immune function in normal mice and the underlying mechanism.</p><p><b>METHOD</b>SRBC and ovalbumin were employed as antigens to be injected to mice, respectively. Three doses of R. uniforum polysaccharide (50, 100, 200 mg x kg(-1) x d(-1)) were given orally for seven days. After the secondary immunization, the level of corresponding antibody and the concentration of serum IL-2, IFN-gamma were determined.</p><p><b>RESULT</b>The levels of antibodies (anti-SRBC and anti-ovalbumin) and cytokines (IL-2 and IFN-gamma) in median dose group of R. uniforum polysaccharide were all significantly higher than those in control groups (P <0.05).</p><p><b>CONCLUSION</b>R. uniforum polysaccharide could enhance the immune function in normal mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Polysaccharides
/
Blood
/
Sheep
/
Random Allocation
/
Chemistry
/
Ovalbumin
/
Interferon-gamma
/
Interleukin-2
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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