Studies on cyclodextrin inclusion complexes of Dragon's blood and its tablets preparation / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2066-2070, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-283796
ABSTRACT
<p><b>OBJECTIVE</b>To study the cyclodextrin inclusion complexes of Dragon's blood for improving the drug solubility and the preparation.</p><p><b>METHOD</b>The inclusion complexes were prepared with beta-cyclodextrin, HP-beta-cyclodextrin, SBE-beta-cyclodextrin and confirmed by DTA. The activity of the inclusion complex was tested by animal experiments. Inclusion complexes tablets were prepared and the dissolution test was performed.</p><p><b>RESULT</b>The solubility of inclusion complexes was increased to 13. 75-168. 39 times. The activity of the inclusion complex was markedly improved, and dissolution rate was 78.69%.</p><p><b>CONCLUSION</b>The cyclodextrin inclusion complexes of Dragon's blood have a good solubility, dissolution rate and pharmacological activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Solubility
/
Tablets
/
Drugs, Chinese Herbal
/
Plant Extracts
/
Chemistry
/
Cyclodextrins
/
Beta-Cyclodextrins
/
Drug Stability
/
2-Hydroxypropyl-beta-cyclodextrin
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article
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