Function of peripheral blood Th17 cells in patients with multiple myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1187-1189, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-283956
ABSTRACT
This study was aimed to investigate the effects of peripheral blood Th17 cells and their secreting IL-17, IL-21 in the occurrence and development of multiple myeloma (MM). A total of 55 patients with MM were divided into non-remission group (group A , n = 30), remission group (group B, n = 25); healthy volunteers were used as control group (group C , n = 30). The concentration of IL-17, IL-21 and IL-6 in the peripheral blood mononuclear cell (PBMNC) culture supernatant were determined with ELISA. The ratio of Th7 cells in PBMNC was determined by flow cytometry. The results showed that IL-17, IL-21 levels and ratio of Th17 cells in group A were much higher than those in group B and C (P < 0.05), IL-17, IL-21 and the ratio of Th17 cells between group B and group C were not significantly different (P > 0.05); IL-17 level in non-remission MM group positively correlated with IL-6 level (r = 0.782, P < 0.05), IL-21 level in non-remission MM group positively correlated with IL-6 level (r = 0.778, P < 0.05). It is concluded that Th17 cells as a initiating factor may be involved in the immune pathogenesis of MM patients, promoting the progress of the disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Case-Control Studies
/
Interleukins
/
Interleukin-6
/
Interleukin-17
/
Th17 Cells
/
Metabolism
/
Multiple Myeloma
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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