MicroRNA-193b expression in newly diagnosed leukemia patients and its significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 843-846, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-284023
ABSTRACT
This study was aimed to quantitatively detect the levels of microRNA-193b (miR-193b) in leukemia patients and explore its significance. Real time fluorescent quantitative PCR was used to detect the relative expression level of miR-193b. The expression changes of miR-193b in various types of leukemia were analyzed. Then the relationship among miR-193b expression, parts of laboratory index and the response to chemotherapy was analyzed as well. The results showed that miR-193b expression level in acute promyelocytic leukemia (APL) and chronic myeloid leukemia (CML) patients was not lower than that in normal group (P > 0.05). Except for APL, miR-193b expression level in acute myeloid leukemia (AML) patients was lower than that in normal group (P < 0.05). In AML (except for APL) patients, there was no correlation between white blood cell count (P > 0.05), the expression of CD34 (P > 0.05) and miR-193b expression level, but there was negative correlation between chemotherapy response and miR-193b expression level (P < 0.05). It is concluded that miR-193b expression level may be correlated with susceptibility of cells to chemotherapy in AML (except for APL) patients. miR-193b maybe become a new target in AML (except for APL) therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Tissue Donors
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Leukemia, Promyelocytic, Acute
/
MicroRNAs
/
Diagnosis
/
Genetics
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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