Progress of study on PML in cancer stem cell of hematologic malignancies / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 796-800, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-284032
ABSTRACT
The promyelocytic leukemia protein (PML), encoded by PML gene, plays a tumor suppressor in acute promyelocytic leukemia and other hematologic malignancies. Recent evidence indicates that PML involves in regulating multiple cell biological function, regulates self-renewal and maintains stable function in stem cell/cancer stem cell of multiple tissues, leading to drug resistance of cancer. This review summarizes the latest research advances about the relationship and therapeutic options between PML and cancer stem cell of hematologic neoplasms, aiming to propose a new avenue for blood cancer treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
Neoplastic Stem Cells
/
Blood
/
Nuclear Proteins
/
Hematologic Neoplasms
/
Tumor Suppressor Proteins
/
Promyelocytic Leukemia Protein
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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