Bone mineral density in hypogonadal men remains low after long-term testosterone replacement / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 117-121, 2002.
Article
in English
| WPRIM
| ID: wpr-284061
ABSTRACT
<p><b>AIM</b>In 11 congenital hypogonadal men, the bone mineral density (BMD) values were determined to assess the effect of long-term androgen replacement therapy (ART) on skeletal integrity.</p><p><b>METHODS</b>Eleven congenital hypogonadal men, including 8 isolated gonadotropin deficiency patients, 2 Kallmann's syndrome and 1 vanishing testes syndrome were recruited and treated with 250 mg of testosterone enanthate intramuscularly every 4 weeks for 7-43 years (mean+/-SD 21.5 +/-13 years). In these patients and a group of 10 healthy young men (controls), the whole and trabecular BMDs were examined at the distal end of radius by means of a peripheral quantitative computerized tomography device.</p><p><b>RESULTS</b>The whole radial BMD in hypogonadal men was significantly less in the patients than in the healthy men (498+/-115 and 725+/-134 mg/cm(3), respectively; P<0.01); the trabecular BMD was also lower in the hypogonadal men (199+/-80 and 375+/-89 mg/cm(3); P< 0.01). The whole radial BMD values in 10 of 11 hypogonadal men were at least 1 SD below the mean value for healthy young men; 2 hypogonadal men had BMD values more than 2.5 SD lower than the healthy mean. Additionally, the whole radial BMD showed a significant negative correlation with the patient's age at the initiation of ART (r = 0.748, P<0.01). The serum level of bone-specific alkaline phosphatase and the urinary level of deoxypyridinoline were not significantly different between the two groups.</p><p><b>CONCLUSION</b>Osteopenia persists in the hypogonadal men after long-term ART, suggesting that such patients have a persistent defect in bone development not alleviated by androgen replacement.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Testosterone
/
Bone Density
/
Age Factors
/
Kallmann Syndrome
/
Hormone Replacement Therapy
/
Cryptorchidism
/
Therapeutic Uses
/
Drug Therapy
/
Hypogonadism
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2002
Type:
Article
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