Microdeletions in the Y chromosome of patients with idiopathic azoospermia / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 111-115, 2002.
Article
in English
| WPRIM
| ID: wpr-284062
ABSTRACT
<p><b>AIM</b>To evaluate the occurrence and prevalence of microdeletions in the gamma chromosome of patients with azoospermia.</p><p><b>METHODS</b>DNA from 29 men with idiopathic azoospermia was screened by polymerase chain reaction (PCR) analysis with a set of gamma chromosome specific sequence-tagged sites (STSs) to determine microdeletions in the gamma chromosome.</p><p><b>RESULTS</b>Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia, resulting in an estimated frequency of deletions of 10.7% in idiopathic azoospermia men.</p><p><b>CONCLUSION</b>We conclude that PCR analysis is useful for the diagnosis of microdeletions in the Y chromosome, which is important when deciding the suitability of a patient for assisted reproductive technology such as testicular sperm extracion-intracytoplasmic sperm injection (TESE-ICSI).</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligospermia
/
Prolactin
/
Testosterone
/
Blood
/
Luteinizing Hormone
/
Base Sequence
/
Heterochromatin
/
Polymerase Chain Reaction
/
Sequence Tagged Sites
/
Sequence Deletion
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2002
Type:
Article
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