Expression and clinical significance of circadian gene Per2 in non-small cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 129-131, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-284224
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of Per2 in non-small cell lung cancer (NSCLC), and analyze its clinical significance.</p><p><b>METHODS</b>The expression of Per2 was determined in 60 NSCLC and 20 normal lung tissues by immunohistochemical assay, and the relationship between Per2 expression and clinicopathological features was analyzed.</p><p><b>RESULTS</b>The positive expression rates of Per2 in NSCLC and normal lung tissues were 71.7% and 95.0%, respectively (P < 0.05). The expression of Per2 in NSCLC was correlated with pathological differentiation and TNM stage (P < 0.05).</p><p><b>CONCLUSION</b>The expression of Per2 in NSCLC is decreased. The negative expression of Per2 may contribute to the development and invasion in NSCLC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
General Surgery
/
Smoking
/
Gene Expression Regulation, Neoplastic
/
Carcinoma, Non-Small-Cell Lung
/
Period Circadian Proteins
/
Neoplasm Grading
/
Lung Neoplasms
/
Lymphatic Metastasis
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2013
Type:
Article
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