Voxel-based Relaxometry of transverse relaxation rate with gradient echo R2(*) in patients with multiple system atrophy / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 450-454, 2012.
Article
in English
| WPRIM
| ID: wpr-284351
ABSTRACT
<p><b>OBJECTIVE</b>To explore the transverse relaxation rate with gradient echo R2(*) changes in patients with Parkinsonian variant of multiple system atrophy (MSA-P) with a voxel-based analysis of R2(*) map.</p><p><b>METHODS</b>Whole brain structural images and multi-echo T2(*) weighted image were acquired in 27 patients with probable MSA-P and 24 healthy individuals. R2(*) maps of the MSA-P were compared with the controls by voxel-based methods.</p><p><b>RESULT</b>Compared with the controls, MSA-P patients showed significant R2(*) decrease bilaterally in brain stem, cerebellar hemispheres, insular lobe, temporal lobes, caudate nucleus, and corpus callosum (P<0.005).</p><p><b>CONCLUSIONS</b>R2(*) can reveal the significant brain involvements of MSA-P. The introduction of gradient echo may increase the sensitivity, although the susceptible artifact may interfere the detection efficiency of R2(*).</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Image Processing, Computer-Assisted
/
Magnetic Resonance Imaging
/
Case-Control Studies
/
Sensitivity and Specificity
/
Multiple System Atrophy
/
Diagnosis
/
Methods
Type of study:
Diagnostic study
/
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2012
Type:
Article
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