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Effects of beta-asarone on expression of c-fos in kindling epilepsy rat brain / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 534-536, 2008.
Article in Chinese | WPRIM | ID: wpr-284449
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of beta-asarone on expression of immediately early gene c-fos in kindling epilepsy rat brain.</p><p><b>METHOD</b>The rats were randomly divided in to beta-asarone groups (200, 100, 50 mg x kg(-1) x d(-1)), difetoin control group (36 mg x kg(-1)) and model group. The remedy was administered orally. The effects were observed in kindling epilepsy model induced by penicillin, then the expression of c-fos were determined by western blot (hippocampus) and immunohistochemical techniques (cortex).</p><p><b>RESULT</b>Beta-asarone could significantly increase the expression of c-fos in kindling epilepsy rat brain, and show its quantity-effect relation. The expression of c-fos in hippocampus was (1139.45 +/- 155.56), (1109.56 +/- 134.03), (1103.73 +/- 235.82) CNT x mm2 in beta-asarone groups, 920.54 +/- 203.20 in model control group, and 1106.26 +/- 186.24 in difetoin group, respectively. The number of c-fos positive cell was 87.1 +/- 2.2, 76.3 +/- 1.3 and 59.9 +/- 1.3 in beta-asarone groups, 39.3 +/- 2.6 in model control group, and 95.2 +/- 1.1 in difetoin group, respectively.</p><p><b>CONCLUSION</b>Beta-asarone can obviously increase the expression of c-fos in epilepsy rat brain. It is one of important response to epilepsy.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Brain / Immunohistochemistry / Random Allocation / Gene Expression / Blotting, Western / Proto-Oncogene Proteins c-fos / Rats, Sprague-Dawley / Drug Therapy / Epilepsy Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Brain / Immunohistochemistry / Random Allocation / Gene Expression / Blotting, Western / Proto-Oncogene Proteins c-fos / Rats, Sprague-Dawley / Drug Therapy / Epilepsy Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2008 Type: Article