Clinical study on intervention of liuwei dihuang pill on hormonotherapy in treating nephrotic syndrome / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 107-110, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-284501
ABSTRACT
<p><b>OBJECTIVE</b>To observe the intervention of liuwei dihuang pill (LDP) on therapeutic effectiveness and adverse reaction of hormonotherapy in treating nephrotic syndrome.</p><p><b>METHODS</b>Patients allocated in two groups were medicated with initial dose of prednisone 1 mg/kg once a day at 8 am in the morning. After being medicated for 8 to 12 weeks, the dose of prednisone was decreased by 5.0 mg every 2 weeks till 0.5 mg/kg per day. Then the medication was changed to that two days' dosage orally take once a day with the daily dose reduced by 5.0 mg/kg every 2 to 3 weeks, and maintained at 0.4 mg/kg once every two days. At same time, necessary symptomatic treatment was given. To the treated group oral administration of LDP 8 capsules was given additionally, 3 times per day until prednisone decreased to maintenance dose.</p><p><b>RESULTS</b>Therapeutic effect in the treated group was significant better than that in the control group (P < 0.05). Urinary protein, plasma albumin, triglyceride (TG) and total cholesterol (TC) in both groups were obviously improved (P < 0.05 or P < 0.01). However, as compared with the control group, the improvement was better, and the recurrent rate was lower (P < 0.05) in the treated group. Scores of Yin-deficiency caused excessive Fire syndrome and incidence rate of adverse reaction in the treated group were lower than those in the control group (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>LDP can markedly improve the therapeutic effectiveness and counteract the adverse reaction of hormonotherapy in treating nephrotic syndrome, and reduce the recurrence of the disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prednisone
/
Drugs, Chinese Herbal
/
Follow-Up Studies
/
Yin Deficiency
/
Therapeutic Uses
/
Drug Therapy
/
Drug Therapy, Combination
/
Phytotherapy
/
Nephrotic Syndrome
/
Obesity
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2005
Type:
Article
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