Renal tubular protection of shenqi fuzheng injection in treating primary nephrotic syndrome / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the effect and mechanism of Shenqi Fuzheng injection (SFI) on renal tubule in treating patients with primary nephrotic syndrome (PNS).</p><p><b>METHODS</b>Eighty patients with PNS were randomly divided into two groups, 40 patients in the control group were treated by conventional therapy mainly with glucocorticoids; 40 patients in the treated group treated by conventional therapy plus intravenous injection of SFI additionally. The changes of serum albumin (sALB), urinary protein in 24 hrs (UP/24h), urinary levels of retinal binding protein (RBP), beta2 microglobulin (beta2-MG) and N-acetyl-D-glucosaminidase (NAG) as well as blood lipids before and after treatment were observed.</p><p><b>RESULTS</b>After treatment, level of sALB increased and urinay levels of RBP, beta2-MG, NAG, UP/24h decreased in the treated group, as compared with those in the control group, showing significant difference (P < 0.05 or P < 0.01). Blood lipids level abated significantly after treatment in both groups (P < 0.01), comparison between them, levels of TC and LDL-C in the treated group were significantly lower than those in the control group (P < 0.01).</p><p><b>CONCLUSION</b>SFI has protective effect on renal tubule in patients with PNS, also has effect on lowering blood lipids.</p>