Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 896-904, 2008.
Article
in English
| WPRIM
| ID: wpr-284729
ABSTRACT
<p><b>AIM</b>To complete comprehensive haplotype analysis of USP26 for both fertile and infertile men.</p><p><b>METHODS</b>Two hundred infertile men with severe oligospermia or non-obstructive azoospermia were subjected to sequence analysis for the entire coding sequences of the USP26 gene. Two hundred men with proven fertility were genotyped by primer extension methods. Allele/genotype frequencies, linkage disequilibrium (LD) characteristics and haplotypes of fertile men were compared with infertile men.</p><p><b>RESULTS</b>The allele frequencies of five single nucleotide polymorphisms (370-371insACA, 494T>C, 576G>A, ss6202791C>T, 1737G>A) were significantly higher in infertile patients than control subjects. The major haplotypes in infertile men were TACCGA (28% of the population), TGCCGA (15%), TACCAA (8%), TGCCAA (6%), TATCAA (5%) and CATCAA (5%). The major haplotypes for the control subjects were TACCGA (58% of the population), CACCGA (7%), CATCGA (6%) and TGCCGA (5%). Haplotypes TGCCGA, TATCAA, CATCAA, CATCGC, TACCAA and TGCCAA were over-transmitted in patients with spermatogenic defect, whereas haplotypes TACCGA, CACCGA, and CATCGA were under-transmitted in these patients.</p><p><b>CONCLUSION</b>Some USP26 alleles and haplotypes are associated with spermatogenic defect in the Han nationality in Taiwan, China.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligospermia
/
Physiology
/
Polymorphism, Genetic
/
Spermatogenesis
/
Taiwan
/
Genetic Variation
/
Haplotypes
/
Cysteine Endopeptidases
/
Linkage Disequilibrium
/
Multigene Family
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Journal of Andrology
Year:
2008
Type:
Article
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