When is a bone scan study appropriate in asymptomatic men diagnosed with prostate cancer? / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 890-895, 2008.
Article
in English
| WPRIM
| ID: wpr-284730
ABSTRACT
<p><b>AIMS</b>To determine when a bone scan investigation is appropriate in asymptomatic men diagnosed with prostate cancer.</p><p><b>METHODS</b>Between November 2005 and July 2006, 317 men with prostate cancer underwent a bone scan study; 176 men fulfilled the inclusion criteria. Prostate-specific antigen (PSA) cut-offs as well as univariate and multivariate logistic regression analyses using digital rectal examination finding, biopsy Gleason scores and age were performed to determine when a bone scan study is likely to be of value.</p><p><b>RESULTS</b>Only 1/61 men (1.6%) with a serum PSA 20 ng/mL had a positive bone scan. However, 2/38 men (4.7%) with a serum PSA 20.1-40.0 ng/mL, 3/20 men (15%) with a serum PSA 40.1-60.0 ng/mL, 7/19 men (36.8%) with a serum PSA 60.1-100.0 ng/mL and 19/38 men (50%) with a serum PSA > 100.0 ng/mL had positive bone scans. Univariate and multivariate logistic regression analyses were uninformative in these groups.</p><p><b>CONCLUSION</b>Based on our findings, a bone scan is of limited value in asymptomatic prostate cancer patients presenting PSA =or< 20 ng/mL. Therefore, this investigation can be eliminated unless a curative treatment is contemplated. Furthermore, digital rectal examination finding, biopsy Gleason score and age are unhelpful in predicting those who might harbor bone metastasis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatic Neoplasms
/
Bone and Bones
/
Bone Neoplasms
/
Diagnostic Imaging
/
Radionuclide Imaging
/
Technetium Tc 99m Medronate
/
Predictive Value of Tests
/
Retrospective Studies
/
Analysis of Variance
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2008
Type:
Article
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