Efficacy of non-penetrating trabecular surgery for open angle glaucoma: a meta-analysis / 中华医学杂志(英文版)

ABSTRACT

<p><b>BACKGROUND</b>Non-penetrating trabecular surgery is a new filtrating surgery without opening in ternal trabecular structures. This study was to estimate the overall efficacy of non-penetrating trabecular surgery for open angle glaucoma.</p><p><b>METHODS</b>The published articles selected for this study were obtained by a computerised Medline and China Biological Medicine Disk search of the literature and a manual search of the bibliographies of relevant articles. Articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using the statistical techniques of meta-analysis.</p><p><b>RESULTS</b>A total of 37 articles were included in the meta-analysis. The pooled complete success rates of non-penetrating trabecular surgery with different techniques were deep sclerectomy single, 69.7% (95% CI 58.5% - 81.0%); deep sclerectomy with collagen implant, 59.4% (95% CI 47.0% - 71.8%); deep sclerectomy with reticulated hyaluronic acid implant, 71.1% (95% CI 56.8% - 85.3%); and viscocanalostomy, 72.0% (95% CI 57.6% - 86.4%). The overall weighted complete success rate of non-penetrating trabecular surgery was 67.8% (95% CI 61.4% - 74.3%).</p><p><b>CONCLUSIONS</b>Non-penetrating trabecular surgery is the best available therapy method for medically uncontrolled open angle glaucoma with a complete success rate of over 60%. But the different techniques cannot belie the complete success rate of non-penetrating trabecular surgery.</p>