Genetic and environmental risk factors for primary open-angle glaucoma / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 706-710, 2004.
Article
in English
| WPRIM
| ID: wpr-284928
ABSTRACT
<p><b>BACKGROUND</b>Primary open-angle glaucoma (POAG) is characterized by optic nerve damage and consists of a group of genetically heterogeneous disorders. This study was to investigate the associations of genetic and environmental factors with POAG in a hospital-based Chinese population.</p><p><b>METHODS</b>Thirty-two adult onset POAG patients and 96 age-sex matched control subjects were studied by multivariable logistic regression analysis for the relationships between POAG and its risk factors including family history, diabetes, hypertension, cardiovascular diseases, cigarette smoking, alcohol consumption and polymorphisms of the myocilin and the optineurin genes.</p><p><b>RESULTS</b>Univariate analysis showed that POAG was related to family history, cardiovascular disease, alcohol consumption and a myocilin sequence alteration (T353I) (P < 0.04). Multivariable logistic regression analysis confirmed that POAG was significantly associated with family history (OR = 20.2), hypertension (OR = 3.58), cigarette smoking (OR = 10.8), alcohol consumption (OR = 0.028) and T353I (OR = 6.03, all P < 0.05).</p><p><b>CONCLUSIONS</b>Family history, hypertension, cigarette smoking and T353I in the myocilin gene are risk factors for POAG. Alcohol consumption, however, has a protective effect.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Alcohol Drinking
/
Glycoproteins
/
Smoking
/
Logistic Models
/
Glaucoma, Open-Angle
/
Risk Factors
/
Cytoskeletal Proteins
/
Eye Proteins
/
Genetics
/
Hypertension
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2004
Type:
Article
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