Polymorphic analysis of two Y chromosome short tandem repeat loci in Chinese Chengdu Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 683-684, 2006.
Article
in Zh
| WPRIM
| ID: wpr-285049
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To reveal the distribution of genetic polymorphism of two novel Y chromosome short tandem repeat (Y-STR) loci (DYS508, DYS516) in Chinese Chengdu Han population.</p><p><b>METHODS</b>Two Y-STR loci were amplified with PCR. The products of PCR were analyzed with polyacrylamide gel electrophoresis. Each allele of these 2 Y-STR loci was sequenced and the allele ladders were constructed. Alleles of these Y-STR loci were nominated according to recommendations of the International Society of Forensic Genetics (ISFG).</p><p><b>RESULTS</b>Six and 6 alleles were observed in loci DYS508 and DYS516 respectively. The gene diversity of DYS508 and DYS516 was 0.7242 and 0.7931 respectively. The diversity of haplotype for these Y-STR loci was 0.9397. The value of discrimination power and the exclusion chance of paternity for these Y-STR loci were same as the value of haplotype diversity.</p><p><b>CONCLUSION</b>Both Y-STR loci are high genetic polymorphic. They are beneficial to the test of male-female mixtures and paternity identification in forensic science.</p>
Full text:
1
Index:
WPRIM
Main subject:
Paternity
/
Polymorphism, Genetic
/
Haplotypes
/
China
/
Polymerase Chain Reaction
/
Tandem Repeat Sequences
/
Chromosomes, Human, Y
/
Asian People
/
Forensic Genetics
/
Gene Frequency
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Type:
Article