Correlation between the polymorphism of platelet glycoprotein GPIb α Kozak gene and transient ischemic attack / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 561-564, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-285076
ABSTRACT
<p><b>OBJECTIVE</b>Genic susceptibility could increase the risk of transient ischemic attack (TIA). The objective of this study is to investigate the relationship between the polymorphism of platelet glycoprotein GPIb α Kozak gene and TIA in Qindao Han population.</p><p><b>METHODS</b>The polymorphisms of platelet glycoprotein GPIb α Kozak gene -5T/C in TIA patients and normal control were detected with sequence-specific primers polymerase chain reaction (PCR-SSP).</p><p><b>RESULTS</b>The prevalence of the CC genotype and C alleles were significantly higher in TIA patients than in the control group (P<0.05). The positive correlation between C allele and TIA was showed by logistic regression analysis (P=0.016).</p><p><b>CONCLUSION</b>The -5T/C polymorphism of the platelet glycoprotein GPIb α Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Base Sequence
/
Ischemic Attack, Transient
/
Polymerase Chain Reaction
/
Sequence Analysis, DNA
/
Platelet Glycoprotein GPIb-IX Complex
/
Genetic Predisposition to Disease
/
Alleles
/
Gene Frequency
/
Genetics
Type of study:
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Type:
Article
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