Genetic polymorphism of HLA-Cw locus in hematopoietic stem cell transplantation patient and donor population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 528-531, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-285085
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the distribution of genes in HLA-Cw locus from Han population of China in a large scale, and to provide basic data for further study on the genetic characteristics of HLA-Cw locus of this population.</p><p><b>METHODS</b>Totally 1285 unrelated Chinese Han individuals were typed by PCR-SSP, and statistics was utilized to investigate the distribution rules of detected genes.</p><p><b>RESULTS</b>Twenty-three HLA-Cw alleles were identified in Chinese Han population, out of them HLA-Cw*01, *03, *07 and *08 were the commonest genes, which accounted for frequencies of 0.1529, 0.2385, 0.1747 and 0.1004, respectively. Five genes which could not be identified by serological method were deaed HLA-Cw*12, *14, *15, *16 and *17. Hardy-Weinberg test showed that the observed genetic polymorphism distribution values were correspondent with the expected (chi-square=73.74, df=98, P>0.5).</p><p><b>CONCLUSION</b>This study may serve a full-scale scientific genetic parameters of HLA-Cw genes for Chinese Han population studies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Tissue Donors
/
HLA-C Antigens
/
Polymerase Chain Reaction
/
Hematopoietic Stem Cell Transplantation
/
Alleles
/
Gene Frequency
/
Genetics
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Type:
Article
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