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The genetic polymorphism of HLA-DQA1 and HLA-DQB1 genes of Chinese Han population in Jiangsu area is studied by PCR-sequence-based typing / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 463-465, 2006.
Article in Chinese | WPRIM | ID: wpr-285098
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the polymorphism of HLA-DQA1 and DQB1 genes of Han population in Jiangsu of China.</p><p><b>METHODS</b>The alleles and haplotypes frequencies of HLA-DQA1 and DQB1 genes in 100 unrelated healthy individuals were analyzed by using polymerase chain reaction-sequence-based typing (PCR-SBT).</p><p><b>RESULTS</b>Among the 7 DQA1 alleles detected, the most common allele was DQA1*0301/02/03 with a frequency of 29.5%, which was followed by DQA1*0501, DQA1*0102 and DQA1*0201 with frequencies of 18.5%, 17.0% and 12.5%, respectively. Of the 13 DQB1 alleles detected, DQB1*0201/02 allele (21.5%) was the most frequent allele, followed by DQB1*0301/09 (14.5%), DQB1*0303 (13.5%) and DQB1*0603 (11.5%). The most common DQA1 vs DQB1 haplotype was DQA1*0301/02/03 vs DQB1*0303 with a frequency of 12.5%, which was followed by the DQA1*0201-DQB1*0201/02 (10.5%),DQA1*0501-DQB1*0201/02 (9.5%) and DQA1*0501-DQB1*0301/09 (7.0%).</p><p><b>CONCLUSION</b>The distribution of HLA-DQ alleles and haplotypes in Jiangsu Han population shares some genetic characteristics with other population in northern of China, but has its own characteristics. The data will provide useful information for anthropology, organ transplantation and disease association studies.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Haplotypes / HLA-DQ Antigens / China / Polymerase Chain Reaction / Asian People / Alleles / HLA-DQ alpha-Chains / HLA-DQ beta-Chains / Gene Frequency Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Haplotypes / HLA-DQ Antigens / China / Polymerase Chain Reaction / Asian People / Alleles / HLA-DQ alpha-Chains / HLA-DQ beta-Chains / Gene Frequency Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2006 Type: Article