alpha-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet
Nutrition Research and Practice
;
: 195-200, 2012.
Article
in English
| WPRIM
| ID: wpr-28526
ABSTRACT
The purpose of this study was to investigate the effects of alpha-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). After 4 weeks of feeding, rats on the HFD were divided into three groups by randomized block design; the first group received the high-fat-diet (n = 10), and the second group received the HFD administered with 0.25% alpha-lipoic acid (0.25LA), and the third group received the high-fat diet with 0.5% alpha-lipoic acid (0.5LA). The high fat diet with alpha-lipoic acid supplemented groups had significantly inhibited body weight gain, compared to that in the HFD group (P < 0.05). Organ weights of rats were also significantly reduced in liver, kidney, spleen, and visible fat tissues in rats supplemented with alpha-lipoic acid (P < 0.05). Significant differences in plasma lipid profiles, such as total lipids, total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein, were observed between the HFD and 0.5LA groups. The atherogenic index and the plasma high density lipoprotein-cholesterol/total cholesterol ratio improved significantly with alpha-lipoic acid supplementation in a dose-dependent manner (P < 0.05). Total hepatic cholesterol and total lipid concentration decreased significantly in high fat fed rats supplemented with alpha-lipoic acid in a dose-dependent manner (P < 0.05), whereas liver triglyceride content was not affected. In conclusion, alpha-lipoic acid supplementation had a positive effect on weight gain and plasma and liver lipid profiles in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Plasma
/
Spleen
/
Triglycerides
/
Body Weight
/
Weight Gain
/
Weight Loss
/
Cholesterol
/
Thioctic Acid
/
Rats, Sprague-Dawley
Limits:
Animals
Language:
English
Journal:
Nutrition Research and Practice
Year:
2012
Type:
Article
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